Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte; Yannick Estevez; Robert H. Gilman; Walter H. Lewis; Rosario Rojas; Michel Sauvain; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1055/s-2008-1034330

Anti-infective and cytotoxic compounds present in Blepharodon nitidum

José C. Aponte
, Yannick Estevez
, Robert H. Gilman
, Walter H. Lewis
, Rosario Rojas
, Michel Sauvain
, Abraham J. Vaisberg
, Gerald B. Hammond

Facultad de Ciencias e Ingeniería

University of Louisville
Université de Toulouse
Johns Hopkins Bloomberg School of Public Health
Universidad Peruana Cayetano Heredia
Washington University School of Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

20 Citas (Scopus)

Resumen

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Idioma original	Inglés
Páginas (desde-hasta)	407-410
Número de páginas	4
Publicación	Planta medica
Volumen	74
N.º	4
DOI	https://doi.org/10.1055/s-2008-1034330
Estado	Publicada - mar. 2008

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title = "Anti-infective and cytotoxic compounds present in Blepharodon nitidum",

abstract = "A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.",

keywords = "Anti-infective, Antileishmania, Asclepiadaceae, Blepharodon nitidum, Cytotoxic, Hydroperoxycycloartanes",

author = "Aponte, \{Jos{\'e} C.\} and Yannick Estevez and Gilman, \{Robert H.\} and Lewis, \{Walter H.\} and Rosario Rojas and Michel Sauvain and Vaisberg, \{Abraham J.\} and Hammond, \{Gerald B.\}",

year = "2008",

month = mar,

doi = "10.1055/s-2008-1034330",

language = "Ingl{\'e}s",

volume = "74",

pages = "407--410",

journal = "Planta medica",

issn = "0032-0943",

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TY - JOUR

T1 - Anti-infective and cytotoxic compounds present in Blepharodon nitidum

AU - Aponte, José C.

AU - Estevez, Yannick

AU - Gilman, Robert H.

AU - Lewis, Walter H.

AU - Rojas, Rosario

AU - Sauvain, Michel

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2008/3

Y1 - 2008/3

N2 - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

AB - A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en- 3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

KW - Anti-infective

KW - Antileishmania

KW - Asclepiadaceae

KW - Blepharodon nitidum

KW - Cytotoxic

KW - Hydroperoxycycloartanes

UR - https://www.scopus.com/pages/publications/42549130281

U2 - 10.1055/s-2008-1034330

DO - 10.1055/s-2008-1034330

M3 - Artículo

C2 - 18484532

AN - SCOPUS:42549130281

SN - 0032-0943

VL - 74

SP - 407

EP - 410

JO - Planta medica

JF - Planta medica

IS - 4

ER -

Anti-infective and cytotoxic compounds present in Blepharodon nitidum

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