TY - JOUR
T1 - Antibiotic resistance in a very remote Amazonas community
AU - Bartoloni, Alessandro
AU - Pallecchi, Lucia
AU - Rodríguez, Hugo
AU - Fernandez, Connie
AU - Mantella, Antonia
AU - Bartalesi, Filippo
AU - Strohmeyer, Marianne
AU - Kristiansson, Charlotte
AU - Gotuzzo, Eduardo
AU - Paradisi, Franco
AU - Rossolini, Gian Maria
PY - 2009/2
Y1 - 2009/2
N2 - In a very remote human community of the Peruvian Amazonas with minimal antibiotic exposure, high levels of acquired resistance to the oldest antibiotics (ampicillin, tetracycline, trimethoprim/sulfamethoxazole, streptomycin and chloramphenicol) were detected in commensal Escherichia coli, with remarkable diversity of resistant clones and of resistance genes and plasmids. This pattern was similar overall to that previously observed in a very remote community of Bolivia. It was also similar to that observed in the nearest urban area, except for a lower dominance of resistant isolates and the absolute lack of quinolone resistance in the remote community. Present findings suggest that antibiotic resistance observed in remote communities with minimal antibiotic exposure is a general phenomenon contributed by complex mechanisms and provide new insights into the mechanisms involved in this phenomenon.
AB - In a very remote human community of the Peruvian Amazonas with minimal antibiotic exposure, high levels of acquired resistance to the oldest antibiotics (ampicillin, tetracycline, trimethoprim/sulfamethoxazole, streptomycin and chloramphenicol) were detected in commensal Escherichia coli, with remarkable diversity of resistant clones and of resistance genes and plasmids. This pattern was similar overall to that previously observed in a very remote community of Bolivia. It was also similar to that observed in the nearest urban area, except for a lower dominance of resistant isolates and the absolute lack of quinolone resistance in the remote community. Present findings suggest that antibiotic resistance observed in remote communities with minimal antibiotic exposure is a general phenomenon contributed by complex mechanisms and provide new insights into the mechanisms involved in this phenomenon.
KW - Antibiotic resistance
KW - Commensal bacteria
KW - Escherichia coli
KW - Peruvian Amazonas
KW - Remote community
UR - https://www.scopus.com/pages/publications/58149197764
U2 - 10.1016/j.ijantimicag.2008.07.029
DO - 10.1016/j.ijantimicag.2008.07.029
M3 - Artículo
C2 - 18947984
AN - SCOPUS:58149197764
SN - 0924-8579
VL - 33
SP - 125
EP - 129
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 2
ER -