Bioactive acridone alkaloids from Swinglea glutinosa

B. Weniger; B. H. Um; A. Valentin; A. Estrada; A. Lobstein; R. Anton; M. Maillé; M. Sauvain

doi:10.1021/np0005762

Bioactive acridone alkaloids from Swinglea glutinosa

B. Weniger
, B. H. Um
, A. Valentin
, A. Estrada
, A. Lobstein
, R. Anton
, M. Maillé
, M. Sauvain

Université de Strasbourg
Université de Montpellier
Universidad Del Valle
Institut de recherche pour le développement (IRD)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

34 Citas (Scopus)

Resumen

A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

Idioma original	Inglés
Páginas (desde-hasta)	1221-1223
Número de páginas	3
Publicación	Journal of Natural Products
Volumen	64
N.º	9
DOI	https://doi.org/10.1021/np0005762
Estado	Publicada - 2001
Publicado de forma externa	Sí

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ODS 3: Salud y bienestar

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10.1021/np0005762

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title = "Bioactive acridone alkaloids from Swinglea glutinosa",

abstract = "A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.",

author = "B. Weniger and Um, \{B. H.\} and A. Valentin and A. Estrada and A. Lobstein and R. Anton and M. Maill{\'e} and M. Sauvain",

year = "2001",

doi = "10.1021/np0005762",

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volume = "64",

pages = "1221--1223",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Bioactive acridone alkaloids from Swinglea glutinosa

AU - Weniger, B.

AU - Um, B. H.

AU - Valentin, A.

AU - Estrada, A.

AU - Lobstein, A.

AU - Anton, R.

AU - Maillé, M.

AU - Sauvain, M.

PY - 2001

Y1 - 2001

N2 - A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

AB - A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

UR - https://www.scopus.com/pages/publications/0034797649

U2 - 10.1021/np0005762

DO - 10.1021/np0005762

M3 - Artículo

C2 - 11575960

AN - SCOPUS:0034797649

SN - 0163-3864

VL - 64

SP - 1221

EP - 1223

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

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