Brucellar Granulomas as Focal Parenchymal Central Nervous System Lesions: A Case Series

Brucella spp. is a known cause of necrotizing granulomas that can involve any organ in the body. Central nervous system involvement is a rare form of presentation for Brucella infection; however, it may occur due to hematogenous spread of the bacteria. The most common presentation of neurobrucellosis is meningoencephalitis; however, in some cases Brucella may form granulomas in the brain parenchyma in the absence of meningeal involvement or characteristic systemic involvement such as fever and arthralgias. We present 2 cases of patients with brucellar granulomas who presented with focal central nervous system lesions in the absence of meningeal signs or any systemic sign of infection.