TY - JOUR
T1 - Clinical correlations of one-carbon metabolism abnormalities
AU - Tolbert, Lelland C.
AU - Monti, John A.
AU - Walter-Ryan, William
AU - Alarcon, Renato D.
AU - Bahar, Bayyinah
AU - Keriotis, John T.
AU - Allison, Jerone G.
AU - Gates, Anita
AU - Antun, Fuad
AU - Smythies, John R.
PY - 1988
Y1 - 1988
N2 - 1. 1. Ninety psychiatric inpatients with a DSM III diagnosis of schizophrenia, mania, or major depression were studied. 2. 2. Upon admission/transfer to the Clinical Studies Unit, and prior to discharge, measurements of symptom severity (BPRS, Ham-D, Young's Mania Scale) and blood samples were obtained. 3. 3. Erythrocytes from these paired (admission and discharge) blood samples were assayed for methionine adenosyltransferase (MAT) activity and phosphatidylcholine (PC) content. 4. 4. Comparisons were made between the changes in MAT Vmax, or % PC, and changes in symptom severity. 5. 5. For the majority of the patients (79.3% of the schizophrenics; 84.6% of the depressives; and 93.8% of the manics), clinical improvement was associated with a "normalization" of enzyme activity. The association between changes in % PC and clinical response did not achieve significant correlation.
AB - 1. 1. Ninety psychiatric inpatients with a DSM III diagnosis of schizophrenia, mania, or major depression were studied. 2. 2. Upon admission/transfer to the Clinical Studies Unit, and prior to discharge, measurements of symptom severity (BPRS, Ham-D, Young's Mania Scale) and blood samples were obtained. 3. 3. Erythrocytes from these paired (admission and discharge) blood samples were assayed for methionine adenosyltransferase (MAT) activity and phosphatidylcholine (PC) content. 4. 4. Comparisons were made between the changes in MAT Vmax, or % PC, and changes in symptom severity. 5. 5. For the majority of the patients (79.3% of the schizophrenics; 84.6% of the depressives; and 93.8% of the manics), clinical improvement was associated with a "normalization" of enzyme activity. The association between changes in % PC and clinical response did not achieve significant correlation.
KW - major depression
KW - mania
KW - methionine adenosyltransferase
KW - phosphatidylcholine
KW - schizophrenia
UR - https://www.scopus.com/pages/publications/0023897306
U2 - 10.1016/0278-5846(88)90108-X
DO - 10.1016/0278-5846(88)90108-X
M3 - Artículo
C2 - 3406427
AN - SCOPUS:0023897306
SN - 0278-5846
VL - 12
SP - 491
EP - 502
JO - Progress in Neuropsychopharmacology and Biological Psychiatry
JF - Progress in Neuropsychopharmacology and Biological Psychiatry
IS - 4
ER -