Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

Catherine C. Neto; Abraham J. Vaisberg; Bing Nan Zhou; David G.I. Kingston; Gerald B. Hammond

doi:10.1055/s-2000-8583

Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

Catherine C. Neto
, Abraham J. Vaisberg
, Bing Nan Zhou
, David G.I. Kingston
, Gerald B. Hammond

Facultad de Ciencias e Ingeniería

Univ. of Massachusetts-Dartmouth
Department of Fish and Wildlife Conservation

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

39 Citas (Scopus)

Resumen

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI₅₀ values of 6,9 and 8.3/μg/mL respectively.

Idioma original	Inglés
Páginas (desde-hasta)	483-484
Número de páginas	2
Publicación	Planta medica
Volumen	66
N.º	5
DOI	https://doi.org/10.1055/s-2000-8583
Estado	Publicada - 2000

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title = "Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa",

abstract = "Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.",

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AU - Neto, Catherine C.

AU - Vaisberg, Abraham J.

AU - Zhou, Bing Nan

AU - Kingston, David G.I.

AU - Hammond, Gerald B.

PY - 2000

Y1 - 2000

N2 - Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.

AB - Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6,9 and 8.3/μg/mL respectively.

UR - https://www.scopus.com/pages/publications/3242773879

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DO - 10.1055/s-2000-8583

M3 - Artículo

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AN - SCOPUS:3242773879

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ER -

Cytotoxic triterpene acids from the peruvian medicinal plant Polylepis racemosa

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