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Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries

  • M. Ballif
  • , V. Nhandu
  • , R. Wood
  • , J. C. Dusingize
  • , E. J. Carter
  • , C. P. Cortes
  • , C. C. McGowan
  • , L. Diero
  • , C. Graber
  • , L. Renner
  • , D. Hawerlander
  • , S. Kiertiburanakul
  • , Q. T. Du
  • , T. R. Sterling
  • , M. Egger
  • , L. Fenner
  • , S. Ajayi
  • , K. Anastos
  • , J. Bashi
  • , W. Bishai
  • A. Boulle, P. Braitstein, G. Carriquiry, J. E. Carter, P. Cegielski, C. Chimbetete, J. Conrad, M. A. Davies, S. Duda, N. Durier, T. F. Eboua, A. Gasser, E. Geng, L. Hardwicke, C. Hoffmann, R. Huebner, N. Kancheya, P. Kim, D. Lameck, V. Leroy, C. Lewden, M. L. Lindegren, A. Mandalakas, M. Maskew, R. McKaig, L. Mofenson, M. Mpoudi-Etame, B. Okwara, S. Phiri, W. Prasitsuebsai, A. Petit, Hans Prozesky, S. E. Reid, G. Reubenson, A. Sohn, Q. Vo, D. Walker, F. Wehbe, C. Wejse, W. Wester, C. Williams, K. Wools-Kaloustian, Z. Yao, E. Yunihastuti, F. J. Zhang, H. X. Zhao, N. Han, T. P. Merati, D. N. Wirawan, F. Yuliana, R. Ditangco, E. Uy, R. Bantique, P. Phanuphak, K. Ruxrungtham, A. Avihingsanon, T. Mengthaisong, S. Sungkanuparph, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, W. Kotarathititum, T. T. Pham, D. D. Cuong, H. L. Ha, V. K. Nguyen, V. H. Bui, T. T. Cao, A. H. Sohn, B. Petersen, D. A. Cooper, M. G. Law, A. Jiamsakul, D. C. Boettiger, D. K. Wati, L. P.P. Atmikasari, I. Y. Malino, R. Nallusamy, K. C. Chan, P. Lumbiganon, P. Kosalaraksa, P. Tharnprisan, T. Udomphanit, K. Chokephaibulkit, K. Lapphra, W. Phongsamart, O. Wittawatmongkol, K. T.K. Dung, N. V. Lam, P. N. An, N. T. Loan, H. K. Truong, T. Q. Du, N. H. Chau, C. V. Do, M. T. Ha, P. Nipathakosol, A. Kariminia, E. Mutimura, A. Gitembagara, J. Tatwangire, I. Izabelle, T. Niyongabo, C. Twizere, E. Baramperanye, A. Edmonds, M. Yotebieng, I. Azinyue, L. Ayangma, C. Yiannoutsos, S. Ayaya, E. A. Bukusi, J. Lewis-Kulzer, G. Somi, R. Lyamuya, K. Ngonyani, J. Ssali, H. Ssemuwemba, B. B. Mwebesa, A. Kambugu, S. Hermans, F. Nalugoda, K. Jjingo, D. Dickinsonn, B. Eley, C. Fritz, D. Garone, J. Giddy, P. MacPhail, H. Moultrie, J. Ndirangu, S. Pestilli, H. Rabie, J. Stringer, K. Technau, F. Kaeser, O. Keiser, M. Cornell, N. Maxwell, D. M. Zannou, C. Ahouada, J. Akakpo, C. Ahomadegbé, A. Gougounon-Houéto, A. Azon-Kouanou, F. Houngbé, J. Sehonou, S. Koumakpaï, F. Alihonou, M. D'Almeida, I. Hodonou, G. Hounhoui, G. Sagbo, L. Tossa-Bagnan, H. Adjide, J. Drabo, R. Bognounou, A. Dienderé, E. Traore, L. Zoungrana, B. Zerbo, A. B. Sawadogo, J. Zoungrana, A. Héma, I. Soré, G. Bado, A. Tapsoba, D. Yé, F. Kouéta, S. Ouedraogo, R. Ouédraogo, W. Hiembo, M. Gansonré, E. Messou, J. C. Gnokoro, M. Koné, G. M. Kouakou, C. A. Bosse, K. Brou, A. I. Assi, H. Chenal, F. Soppi, A. Minga, Y. Abo, S. P. Eholié, M. D.N. Amego, V. Andavi, Z. Diallo, F. Ello, A. K. Tanon, S. O. Koule, K. C. Anzan, C. Guehi, E. A. Aka, K. L. Issouf, J. C. Kouakou, M. S. N'Gbeche, T. Pety, D. Avit-Edi, K. Kouakou, M. Moh, V. A. Yao, M. A. Folquet, M. E. Dainguy, C. Kouakou, V. T. Méa-Assande, G. Oka-Berete, N. Zobo, P. Acquah, M. B. Kokora, T. F. Eboua, M. Timité-Konan, L. Diecket Ahoussou, J. K. Assouan, M. F. Sami, S. Kouadio, B. Goka, J. Welbeck, A. Sackey, S. N. Owiafe, Z. J. Da Silva, J. Paulo, A. Rodrigues, D. Da Silva, C. Medina, I. Oliviera-Souto, L. Østergaard, A. Laursen, M. Sodemann, P. Aaby, A. Fomsgaard, C. Erikstrup, J. Eugen-Olsen, M. Y. Maïga, F. F. Diakité, A. Kalle, D. Katile, H. A. Traore, D. Minta, T. Cissé, M. Dembelé, M. Doumbia, M. Fomba, A. S. Kaya, A. M. Traoré, H. Traoré, A. A. Toure, F. Dicko, M. Sylla, A. Berthé, H. C. Traoré, A. Koïta, N. Koné, C. N'Diaye, S. T. Coulibaly, M. Traoré, N. Traoré, M. Charurat, G. Alim, S. Dapiap, F. Igbinoba, O. Benson, C. Adebamowo, J. James, Obaseki, P. Osakede, J. Olasode, M. Seydi, P. S. Sow, B. Diop, N. M. Manga, J. M. Tine, C. C. Bassabi, H. S. Sy, A. Ba, A. Diagne, H. Dior, M. Faye, R. D. Gueye, A. D. Mbaye, A. Patassi, A. Kotosso, B. G. Kariyare, G. Gbadamassi, A. Komi, K. E. Mensah-Zukong, P. Pakpame, A. Koko Lawson-Evi, Y. Atakouma, E. Takassi, A. Djeha, A. Ephoévi-gah, S. El-Hadj Djibril, F. Dabis, E. Bissagnene, E. Arrivé, P. Coffie, D. Ekouevi, A. Jaquet, A. J. Sasco, D. Amani, J. C. Azani, E. Balestre, S. Bessekon, F. Bohossou, C. Gilbert, S. Karcher, J. M. Gonsan, J. Le Carrou, S. Lenaud, C. Nchot, K. Malateste, A. R. Yao, B. Siloué, G. Clouet, M. Dosso, A. Doring, A. Kouakou, E. Rabourdin, J. Rivenc, X. Anglaret, B. Ba, J. B. Essanin, A. Ciaranello, S. Datté, S. Desmonde, J. S. Elvis Diby, G. S. Gottlieb, A. G. Horo, S. N. Kangah, D. Malvy, D. Meless, A. Mounkaila-Harouna, C. Ndondoki, C. Shiboski, B. Tchounga, R. Thiébaut, G. Wandeler, C. McGowan, P. Cahn, E. Gotuzzo, M. Wolff, B. Grinsztejn, J. Pape, D. Padgett, J. S. Madero
  • Universität Bern
  • Beijing Ditan Hospital Capital Medical University
  • Center for Infectious Disease Research in Zambia
  • University of Cape Town
  • Desmond Tutu HIV Centre
  • Women's Equity in Access to Care and Treatment
  • United States Agency for International Development Academic Model Providing Access to Healthcare
  • Fundación Arriaran–Facultad de Medicina Universidad de Chile
  • Vanderbilt University School of Medicine
  • University of Ghana
  • Korle Bu Teaching Hospital
  • Centre Integre de Recherches Biocliniques
  • Centre Intégré de Recherches Biocliniques d'Abidjan
  • Ramathibodi Hospital
  • TAHOD Steering Committee
  • Children's Hospital
  • University of Basel
  • Otu University
  • Albert Einstein College of Medicine
  • Centre National Hospitalier et Universitaire (CHNU)
  • Newlands Clinic
  • Foundation for AIDS Research (AMFAR)
  • TREAT Asia
  • Aurum Institute for Health Research
  • Operational and Statistical Team
  • Lighthouse Clinic
  • University of Stellenbosch
  • Bandim Health Project
  • Udayana University
  • Research Institute for Tropical Medicine
  • Thai Red Cross AIDS Research Centre
  • Research Institute for Health Sciences
  • Bach Mai Hospital
  • National Hospital for Tropical Diseases
  • The Kirby Institute
  • TApHOD Steering Committee
  • Penang Hospital
  • Khon Kaen University
  • Siriraj Hospital
  • National Hospital of Pediatrics
  • Children's Hospital 1
  • Children's Hospital 2
  • Rwanda Military Hospital
  • Centre Hospitalo-Universitaire de Kamenge
  • Centre National de Reference en matiere du VIH
  • Kalembelembe Pediatric Hospital
  • Military Hospital of Yaoundé
  • Indiana University-Purdue University Indianapolis
  • Family AIDS Care and Education Services
  • National AIDS Control Program
  • Morogoro Regional Hospital
  • Tumbi Regional Hospital
  • Masaka Regional Referral Hospital
  • Mbarara University of Science and Technology
  • Mulago Hospital
  • Rakai Health Sciences Program
  • Gabarone Independent
  • Red Cross Children's Hospital
  • SolidarMed Zimbabwe
  • Khayelitsha ART Programme and Médecins Sans Frontières
  • McCord Hospital
  • Helen Joseph Hospital
  • Chris Hani Baragwanath Hospital
  • Hlabisa HIV Treatment and Care Programme
  • SolidarMed Mozambique
  • University of the Witwatersrand, Johannesburg
  • CNHU Hubert Maga
  • Centre Hospitalière Universitaire (CHU)
  • Bobo Dioulasso
  • Centre Hospitalière Charles de Gaulle
  • ACONDA-Centre de Prise en Charge de Recherche et de Formation
  • ACONDA-Mother to Child Transmission-Plus
  • Centre National de Transfusion Sanguine
  • CHU de Treichville
  • ACONDA-CePReF
  • ACONDA-MTCT-Plus
  • CIRBA
  • CHU Cocody
  • CHU Yopougon
  • National HIV Program Bissau
  • Hospital National Simao Mendes
  • Aarhus University Hospital
  • Odense University Hospital
  • Statens Serum Institut
  • Aarhus University
  • Hvidovre Hospital
  • CH Gabriel Toure
  • CH Point G
  • CH Gabriel Toure
  • University of Maryland, Baltimore (UMB)
  • National Hospital Abuja
  • University of Benin
  • Obafemi Awolowo Teaching Hospital
  • CHU Fann
  • CH Albert Royer
  • CHU Tokoin
  • Executive Committee
  • PI
  • Administrative Team
  • Vanderbilt University
  • Fundación Huesped
  • Fundación Arriarán
  • Oswaldo Cruz Foundation
  • Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes
  • Hospital Escuela
  • Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

SETTING: Drug resistance threatens tuberculosis (TB) control, particularly among human immunodeficiency virus (HIV) infected persons. OBJECTIVE: To describe practices in the prevention and management of drug-resistant TB under antiretroviral therapy (ART) programs in lower-income countries. DESIGN: We used online questionnaires to collect program-level data on 47 ART programs in Southern Africa (n =14), East Africa (n = 8), West Africa (n = 7), Central Africa (n = 5), Latin America (n = 7) and the Asia-Pacific (n=6 programs) in 2012. Patient-level data were collected on 1002 adult TB patients seen at 40 of the participating ART programs. RESULTS: Phenotypic drug susceptibility testing (DST) was available in 36 (77%) ART programs, but was only used for 22% of all TB patients. Molecular DST was available in 33 (70%) programs and was used in 23% of all TB patients. Twenty ART programs (43%) provided directly observed therapy (DOT) during the entire course of treatment, 16 (34%) during the intensive phase only, and 11 (23%) did not follow DOT. Fourteen (30%) ART programs reported no access to second-line anti-tuberculosis regimens; 18 (38%) reported TB drug shortages. CONCLUSIONS: Capacity to diagnose and treat drugresistant TB was limited across ART programs in lowerincome countries. DOT was not always implemented and drug supplies were regularly interrupted, which may contribute to the global emergence of drug resistance.

Idioma originalInglés
Páginas (desde-hasta)1327-1336
Número de páginas10
PublicaciónInternational Journal of Tuberculosis and Lung Disease
Volumen18
N.º11
DOI
EstadoPublicada - 1 nov. 2014

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

  1. ODS 3: Salud y bienestar
    ODS 3: Salud y bienestar
  2. ODS 5: Igualdad de género
    ODS 5: Igualdad de género

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