(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED₅₀ 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED₅₀ of 228 and 240 mg/g mouse, respectively).