In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

José C. Aponte; Denis Castillo; Yannick Estevez; German Gonzalez; Jorge Arevalo; Gerald B. Hammond; Michel Sauvain

doi:10.1016/j.bmcl.2009.11.033

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

José C. Aponte
, Denis Castillo
, Yannick Estevez
, German Gonzalez
, Jorge Arevalo
, Gerald B. Hammond
, Michel Sauvain

Facultad de Ciencias e Ingeniería

University of Louisville
Université de Toulouse
Université de Toulouse
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

62 Citas (Scopus)

Resumen

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

Idioma original	Inglés
Páginas (desde-hasta)	100-103
Número de páginas	4
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	20
N.º	1
DOI	https://doi.org/10.1016/j.bmcl.2009.11.033
Estado	Publicada - 1 ene. 2010

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abstract = "The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.",

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T1 - In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

AU - Aponte, José C.

AU - Castillo, Denis

AU - Estevez, Yannick

AU - Gonzalez, German

AU - Arevalo, Jorge

AU - Hammond, Gerald B.

AU - Sauvain, Michel

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

AB - The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.

KW - Anti-Leishmanial drugs

KW - Braziliensis

KW - Chalcone

KW - Leishmania amazonensis

KW - Peruviana

UR - https://www.scopus.com/pages/publications/72149098593

U2 - 10.1016/j.bmcl.2009.11.033

DO - 10.1016/j.bmcl.2009.11.033

M3 - Artículo

C2 - 19962891

AN - SCOPUS:72149098593

SN - 0960-894X

VL - 20

SP - 100

EP - 103

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

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