In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts; Leon F. Villegas; Ana Marçalo; Abraham J. Vaisberg; Gerald B. Hammond

doi:10.1021/np0601152

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Gustavo Moura-Letts
, Leon F. Villegas
, Ana Marçalo
, Abraham J. Vaisberg
, Gerald B. Hammond

Facultad de Ciencias e Ingeniería

University of Louisville
Universidad Peruana Cayetano Heredia

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

62 Citas (Scopus)

Resumen

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

Idioma original	Inglés
Páginas (desde-hasta)	978-979
Número de páginas	2
Publicación	Journal of Natural Products
Volumen	69
N.º	6
DOI	https://doi.org/10.1021/np0601152
Estado	Publicada - jun. 2006

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title = "In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa",

abstract = "Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9\% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.",

author = "Gustavo Moura-Letts and Villegas, \{Leon F.\} and Ana Mar{\c c}alo and Vaisberg, \{Abraham J.\} and Hammond, \{Gerald B.\}",

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doi = "10.1021/np0601152",

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T1 - In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

AU - Moura-Letts, Gustavo

AU - Villegas, Leon F.

AU - Marçalo, Ana

AU - Vaisberg, Abraham J.

AU - Hammond, Gerald B.

PY - 2006/6

Y1 - 2006/6

N2 - Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

AB - Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

UR - https://www.scopus.com/pages/publications/33746580850

U2 - 10.1021/np0601152

DO - 10.1021/np0601152

M3 - Artículo

C2 - 16792424

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

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