TY - JOUR
T1 - Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
AU - Chacón-Duque, Juan Camilo
AU - Adhikari, Kaustubh
AU - Fuentes-Guajardo, Macarena
AU - Mendoza-Revilla, Javier
AU - Acuña-Alonzo, Victor
AU - Barquera, Rodrigo
AU - Quinto-Sánchez, Mirsha
AU - Gómez-Valdés, Jorge
AU - Everardo Martínez, Paola
AU - Villamil-Ramírez, Hugo
AU - Hünemeier, Tábita
AU - Ramallo, Virginia
AU - Silva de Cerqueira, Caio C.
AU - Hurtado, Malena
AU - Villegas, Valeria
AU - Granja, Vanessa
AU - Villena, Mercedes
AU - Vásquez, René
AU - Llop, Elena
AU - Sandoval, José R.
AU - Salazar-Granara, Alberto A.
AU - Parolin, Maria Laura
AU - Sandoval, Karla
AU - Peñaloza-Espinosa, Rosenda I.
AU - Rangel-Villalobos, Hector
AU - Winkler, Cheryl A.
AU - Klitz, William
AU - Bravi, Claudio
AU - Molina, Julio
AU - Corach, Daniel
AU - Barrantes, Ramiro
AU - Gomes, Verónica
AU - Resende, Carlos
AU - Gusmão, Leonor
AU - Amorim, Antonio
AU - Xue, Yali
AU - Dugoujon, Jean Michel
AU - Moral, Pedro
AU - González-José, Rolando
AU - Schuler-Faccini, Lavinia
AU - Salzano, Francisco M.
AU - Bortolini, Maria Cátira
AU - Canizales-Quinteros, Samuel
AU - Poletti, Giovanni
AU - Gallo, Carla
AU - Bedoya, Gabriel
AU - Rothhammer, Francisco
AU - Balding, David
AU - Hellenthal, Garrett
AU - Ruiz-Linares, Andrés
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.
AB - Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.
UR - https://www.scopus.com/pages/publications/85058883000
U2 - 10.1038/s41467-018-07748-z
DO - 10.1038/s41467-018-07748-z
M3 - Artículo
C2 - 30568240
AN - SCOPUS:85058883000
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5388
ER -
ODS 10: Reducción de las desigualdades