TY - JOUR
T1 - Multidrug-resistant commensal Escherichia coli in children, Peru and Bolivia
AU - Bartoloni, Alessandro
AU - Pallecchi, Lucia
AU - Benedetti, Marta
AU - Fernandez, Connie
AU - Vallejos, Yolanda
AU - Guzman, Elisa
AU - Villagran, Ana Liz
AU - Mantella, Antonia
AU - Lucchetti, Chiara
AU - Bartalesi, Filippo
AU - Strohmeyer, Marianne
AU - Bechini, Angela
AU - Gamboa, Herlan
AU - Rodríguez, Hugo
AU - Falkenberg, Torkel
AU - Kronvall, Göran
AU - Gotuzzo, Eduardo
AU - Paradisi, Franco
AU - Rossolini, Gian Maria
PY - 2006
Y1 - 2006
N2 - Using a rapid screening method, we investigated the prevalence in fecal carriage of antimicrobial drug-resistant Escherichia coli in 3,174 healthy children from 4 urban settings in Peru and Bolivia. High resistance rates were observed for ampicillin (95%), trimethoprim-sulfamethoxazole (94%), tetracycline (93%), streptomycin (82%), and chloramphenicol (70%). Lower resistance rates were observed for nalidixic acid (35%), kanamycin (28%), gentamicin (21%), and ciprofloxacin (18%); resistance to ceftriaxone and amikacin was uncommon (<0.5%). In a random sample of 1,080 resistant E. coli isolates, 90% exhibited a multidrug-resistance (MDR) phenotype. The 2 most common MDR phenotypes (ampicillin/tetracycline/trimethoprim-sulfamethoxazole and ampicillin/tetracycline/ trimethoprim-sulfamethoxazole/chloramphenicol) could be transferred en bloc in conjugation experiments. The most common acquired resistance genes were blaTEM, tet(A), tet(B), drfA8, sul1, sul2, and catI. These findings underscore the magnitude of the problem of antimicrobial drug resistance in low-resource settings and the urgent need for surveillance and control of this phenomenon.
AB - Using a rapid screening method, we investigated the prevalence in fecal carriage of antimicrobial drug-resistant Escherichia coli in 3,174 healthy children from 4 urban settings in Peru and Bolivia. High resistance rates were observed for ampicillin (95%), trimethoprim-sulfamethoxazole (94%), tetracycline (93%), streptomycin (82%), and chloramphenicol (70%). Lower resistance rates were observed for nalidixic acid (35%), kanamycin (28%), gentamicin (21%), and ciprofloxacin (18%); resistance to ceftriaxone and amikacin was uncommon (<0.5%). In a random sample of 1,080 resistant E. coli isolates, 90% exhibited a multidrug-resistance (MDR) phenotype. The 2 most common MDR phenotypes (ampicillin/tetracycline/trimethoprim-sulfamethoxazole and ampicillin/tetracycline/ trimethoprim-sulfamethoxazole/chloramphenicol) could be transferred en bloc in conjugation experiments. The most common acquired resistance genes were blaTEM, tet(A), tet(B), drfA8, sul1, sul2, and catI. These findings underscore the magnitude of the problem of antimicrobial drug resistance in low-resource settings and the urgent need for surveillance and control of this phenomenon.
UR - https://www.scopus.com/pages/publications/33744927441
U2 - 10.3201/eid1206.051258
DO - 10.3201/eid1206.051258
M3 - Artículo
C2 - 16707045
AN - SCOPUS:33744927441
SN - 1080-6040
VL - 12
SP - 907
EP - 913
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 6
ER -