Natural killer cell activity during measles

D. E. Griffin; B. J. Ward; E. Jauregui; R. T. Johnson; A. Vaisberg

doi:10.1111/j.1365-2249.1990.tb03321.x

Natural killer cell activity during measles

D. E. Griffin
, B. J. Ward
, E. Jauregui
, R. T. Johnson
, A. Vaisberg

Johns Hopkins Hospital

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

54 Citas (Scopus)

Resumen

Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/10⁷ cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

Idioma original	Inglés
Páginas (desde-hasta)	218-224
Número de páginas	7
Publicación	Clinical and Experimental Immunology
Volumen	81
N.º	2
DOI	https://doi.org/10.1111/j.1365-2249.1990.tb03321.x
Estado	Publicada - 1990
Publicado de forma externa	Sí

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title = "Natural killer cell activity during measles",

abstract = "Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.",

keywords = "interferon, interleukin-2, measles, natural killer cells",

author = "Griffin, \{D. E.\} and Ward, \{B. J.\} and E. Jauregui and Johnson, \{R. T.\} and A. Vaisberg",

year = "1990",

doi = "10.1111/j.1365-2249.1990.tb03321.x",

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AU - Griffin, D. E.

AU - Ward, B. J.

AU - Jauregui, E.

AU - Johnson, R. T.

AU - Vaisberg, A.

PY - 1990

Y1 - 1990

N2 - Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

AB - Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 ± 21 lytic units (LU)/107 cells) and 16 individuals with other infectious diseases (149 ± 95 LU) and found it reduced compared with values for adults (375 ± 70 LU; P < 0.001) or children (300 ± 73 LU, P < 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 ± 30 LU) and without (55 ± 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

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KW - interleukin-2

KW - measles

KW - natural killer cells

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DO - 10.1111/j.1365-2249.1990.tb03321.x

M3 - Artículo

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AN - SCOPUS:0025365777

SN - 0009-9104

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EP - 224

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

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Natural killer cell activity during measles

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