Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: A preliminary report

Claudia Machicado; Stéphane Bertani; Patricia Herrera-Velit; Jose Espinoza; Eloy Ruiz; Luis Marcos

doi:10.1590/0037-8682-0180-2017

Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: A preliminary report

Claudia Machicado
, Stéphane Bertani
, Patricia Herrera-Velit
, Jose Espinoza
, Eloy Ruiz
, Luis Marcos

University of Zaragoza
Université de Toulouse
Instituto Nacional de Enfermedades Neoplásicas Eduardo Cáceres Graziani
SUNY/Stony Brook University

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4 Citas (Scopus)

Resumen

Introduction: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients. Methods: In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA. Results: Fas2-ELISA demonstrated negative results in all HCC patients included in this study. Conclusions: The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.

Idioma original	Inglés
Páginas (desde-hasta)	231-233
Número de páginas	3
Publicación	Revista da Sociedade Brasileira de Medicina Tropical
Volumen	51
N.º	2
DOI	https://doi.org/10.1590/0037-8682-0180-2017
Estado	Publicada - 1 mar. 2018

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title = "Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: A preliminary report",

abstract = "Introduction: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients. Methods: In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA. Results: Fas2-ELISA demonstrated negative results in all HCC patients included in this study. Conclusions: The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.",

keywords = "Cholangiocarcinoma, Fasciolosis, Fibrosis, Hepatocellular carcinoma, Liver fluke",

author = "Claudia Machicado and St{\'e}phane Bertani and Patricia Herrera-Velit and Jose Espinoza and Eloy Ruiz and Luis Marcos",

year = "2018",

month = mar,

day = "1",

doi = "10.1590/0037-8682-0180-2017",

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Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: A preliminary report. / Machicado, Claudia; Bertani, Stéphane; Herrera-Velit, Patricia et al.
En: Revista da Sociedade Brasileira de Medicina Tropical, Vol. 51, N.º 2, 01.03.2018, p. 231-233.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru

T2 - A preliminary report

AU - Machicado, Claudia

AU - Bertani, Stéphane

AU - Herrera-Velit, Patricia

AU - Espinoza, Jose

AU - Ruiz, Eloy

AU - Marcos, Luis

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Introduction: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients. Methods: In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA. Results: Fas2-ELISA demonstrated negative results in all HCC patients included in this study. Conclusions: The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.

AB - Introduction: The etiology of several hepatocellular carcinoma (HCC) cases remains largely unknown. Although Fasciola hepatica has been associated with liver fibrosis in Latin America, it has not yet been associated with HCC. This study aimed to determine the existence of specific IgG antibodies against F. hepatica in the serum samples of HCC patients. Methods: In total, 13 serum samples from 13 HCC patients were screened using Fas2-ELISA. Results: Fas2-ELISA demonstrated negative results in all HCC patients included in this study. Conclusions: The pre-existence of F. hepatica infection in HCC patients needs to be further investigated in epidemiological and experimental studies.

KW - Cholangiocarcinoma

KW - Fasciolosis

KW - Fibrosis

KW - Hepatocellular carcinoma

KW - Liver fluke

UR - https://www.scopus.com/pages/publications/85047012774

U2 - 10.1590/0037-8682-0180-2017

DO - 10.1590/0037-8682-0180-2017

M3 - Artículo

C2 - 29768560

AN - SCOPUS:85047012774

SN - 0037-8682

VL - 51

SP - 231

EP - 233

JO - Revista da Sociedade Brasileira de Medicina Tropical

JF - Revista da Sociedade Brasileira de Medicina Tropical

IS - 2

ER -

Negative serology of Fasciola hepatica infection in patients with liver cancer in Peru: A preliminary report

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