TY - JOUR
T1 - One-carbon metabolism disturbances in affective disorders. A preliminary report
AU - Alarcon, Renato D.
AU - Tolbert, Lelland C.
AU - Monti, John A.
AU - Morere, Donna A.
AU - Walter-Ryan, William G.
AU - Kemp, Beverly
AU - Smythies, John R.
PY - 1985/11
Y1 - 1985/11
N2 - Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.
AB - Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.
KW - Mania - Methionine-adenosyl-transferase - One carbon metabolism - Phosphatidylcholine - Unipolar depression
UR - https://www.scopus.com/pages/publications/0022385928
U2 - 10.1016/0165-0327(85)90060-6
DO - 10.1016/0165-0327(85)90060-6
M3 - Artículo
C2 - 2934462
AN - SCOPUS:0022385928
SN - 0165-0327
VL - 9
SP - 297
EP - 301
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 3
ER -