Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives

Belén Zarranz; Andrés Jaso; Ignacio Aldana; Antonio Monge; Séverine Maurel; Eric Deharo; Valérie Jullian; Michel Sauvain

doi:10.1055/s-0031-1296926

Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives

Belén Zarranz
, Andrés Jaso
, Ignacio Aldana
, Antonio Monge
, Séverine Maurel
, Eric Deharo
, Valérie Jullian
, Michel Sauvain

University of Navarra
Université de Toulouse

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

58 Citas (Scopus)

Resumen

New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity against the erythrocytic development of Plasmodium falciparum strain with different chloroquine- resistance status. Quinoxaline 1,4-dioxide derivatives showed superior antimalarial activity in respect to reduced quinoxaline analogues. The best activity was observed with nonsubstituted quinoxaline 1,4-dioxides in positions 6 and 7 of the aromatic ring and with a hydrogen or chloro substituent in para position of the phenyl group.

Idioma original	Inglés
Páginas (desde-hasta)	754-761
Número de páginas	8
Publicación	Arzneimittel-Forschung/Drug Research
Volumen	55
N.º	12
DOI	https://doi.org/10.1055/s-0031-1296926
Estado	Publicada - 2005
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Acceder al documento

10.1055/s-0031-1296926

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{6b07b1a2508744039a64cd9445184007,

title = "Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives",

abstract = "New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity against the erythrocytic development of Plasmodium falciparum strain with different chloroquine- resistance status. Quinoxaline 1,4-dioxide derivatives showed superior antimalarial activity in respect to reduced quinoxaline analogues. The best activity was observed with nonsubstituted quinoxaline 1,4-dioxides in positions 6 and 7 of the aromatic ring and with a hydrogen or chloro substituent in para position of the phenyl group.",

keywords = "Antimalarial agents, Quinoxaline-carbonitrile derivatives, in vitro and in vivo studies, synthesis, β-Hernatin",

author = "Bel{\'e}n Zarranz and Andr{\'e}s Jaso and Ignacio Aldana and Antonio Monge and S{\'e}verine Maurel and Eric Deharo and Val{\'e}rie Jullian and Michel Sauvain",

year = "2005",

doi = "10.1055/s-0031-1296926",

language = "Ingl{\'e}s",

volume = "55",

pages = "754--761",

journal = "Arzneimittel-Forschung/Drug Research",

issn = "0004-4172",

number = "12",

}

TY - JOUR

T1 - Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives

AU - Zarranz, Belén

AU - Jaso, Andrés

AU - Aldana, Ignacio

AU - Monge, Antonio

AU - Maurel, Séverine

AU - Deharo, Eric

AU - Jullian, Valérie

AU - Sauvain, Michel

PY - 2005

Y1 - 2005

N2 - New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity against the erythrocytic development of Plasmodium falciparum strain with different chloroquine- resistance status. Quinoxaline 1,4-dioxide derivatives showed superior antimalarial activity in respect to reduced quinoxaline analogues. The best activity was observed with nonsubstituted quinoxaline 1,4-dioxides in positions 6 and 7 of the aromatic ring and with a hydrogen or chloro substituent in para position of the phenyl group.

AB - New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity against the erythrocytic development of Plasmodium falciparum strain with different chloroquine- resistance status. Quinoxaline 1,4-dioxide derivatives showed superior antimalarial activity in respect to reduced quinoxaline analogues. The best activity was observed with nonsubstituted quinoxaline 1,4-dioxides in positions 6 and 7 of the aromatic ring and with a hydrogen or chloro substituent in para position of the phenyl group.

KW - Antimalarial agents

KW - Quinoxaline-carbonitrile derivatives, in vitro and in vivo studies, synthesis

KW - β-Hernatin

UR - https://www.scopus.com/pages/publications/29744447563

U2 - 10.1055/s-0031-1296926

DO - 10.1055/s-0031-1296926

M3 - Artículo

C2 - 16430030

AN - SCOPUS:29744447563

SN - 0004-4172

VL - 55

SP - 754

EP - 761

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 12

ER -